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Thus, NERD includes a heterogeneous group of patients. One of gloperba pills subgroups includes patients with functional disorders of the esophagus - functional heartburn. The Expert Committee on Functional Disorders of the Esophagus has introduced the concept of “functional heartburn” as a subcategory of NERD, the diagnosis of which is possible after performing a 24-hour pH test (Rome I criteria). may be a yardstick for categorizing patients with heartburn symptoms. Sometimes, even in the case of severe structural changes in the mucosa of the esophagus, with RE, false-negative results of pH-metry are noted, associated with the predominance, for example, of the “alkaline component” in the contents of the refluxate (Author's note).

Classification of colchicine heartburn.

From 30 to 50% of patients with NERD, when conducting pH monitoring in the esophagus, have a normal picture of colchicine exposure indicators, which predetermines the selection of these patients as a subgroup with functional heartburn. As a rule, these are young patients with normal body weight. The apparent female prevalence in this subgroup of patients, noted in several studies, may not actually reflect the true demographic picture, as most patients with functional heartburn shy away from seeking medical attention. It is possible that this prevalence is similar to take colchicine pills of functional bowel disorders among females.

In this regard, it is quite reasonable to consider the central and peripheral mechanisms of nervous regulation and visceral perception in order to buy colchicine online the basis for the development of symptoms in these patients.

  • When considering the mechanisms responsible for the development of GERD symptoms in patients with functional heartburn, comes the understanding of the fact that patients with functional heartburn also represent a heterogeneous group of patients.
  • The presence of classic heartburn symptoms in the absence of esophageal mucosal injury and pathological reflux exposure suggests that there is a subset of patients sensitive to physiological acid concentrations that most normal people do not sense.
  • In another subset of patients, typical heartburn is triggered by non-acid intraesophageal stimuli. Data on them is very scarce, but it is quite certain that these are patients representing quite distinct subgroups that are included in the group of patients with functional heartburn.
  • In contrast to this subcategory of patients, in another part of colcrys online (about 60% of patients with functional heartburn), there is no or very low correlation between heartburn and acid reflux.
  • In half of these patients, the symptom index has less than 50% severity (SI 6.0, in the group with hypersensitive esophagus, a similar picture was observed in 12.9%, in the group with NERD - in 3.87% of cases.

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  • Symptom heartburn in the light of the Rome IV criteria.
  • The journal is included in the List of peer-reviewed scientific publications of the Higher Attestation Commission.
  • Heartburn is one of the most common somatic symptoms. In the Russian Federation it occurs in 40% of people aged from18 to 59 years and in 30% of the population over the age of 60.
  • The article examines in detail the pathophysiology of heartburn in patients with reflux esophagitis (RE) and non-erosive reflux disease (NERD), in which pathological conditions such as hypersensitive esophagus (HE) or functional heartburn (PH) can be detected.

The microscopic study of the mucosa of colcrys drug esophagus is used to diagnose and distinguish between gastroesophageal reflux disease (GERD) and HE from PH. To diagnose the causes of heartburn, FGDS and daily pH-impedance measurements are made. According to the Roman criteria, the IV group of functional disorders of the esophagus includes. functional pain in the chest, FI, HE, globus pharyngeus and functional dysphagia.